Road Agents begins as a pair of outlaws prepares to rob a stagecoach. Donning masks and brandishing six-guns, the bad guys relieve the passengers of their valuables and also make off with a box full of payroll money. As the sheriff organizes a posse, the bandits are seen dividing their loot. The greedier of the two crooks beats up his partner and absconds with their ill-gotten gains. The other bandit, thirsting for revenge, joins the sheriff's posse to track down his former chum.